DNA Repair Enzymes

DNA Repair Enzymes have been shown to repair DNA damage in the skin, from the sun and other sources. They may also protect the skin from future damage, and reduce the signs of sun damage. Examples include photolysomes, from plankton, mitosomes, from the mustard plant Arabidopsis thalania and endosomes, from the microbe, Micrococcus lysate. To date, there aren’t many studies supporting their use in skincare.

Evidence base: Weak

Bhatia N, Berman B, Ceilley RI, Kircik LH. Understanding the Role of Photolyases: Photoprotection and Beyond. J Drugs Dermatol. 2017 May 1;16(5):61-66. 

Rosenthal A, Stoddard M, Chipps L, Herrmann J. Skin cancer prevention: a review of current topical options complementary to sunscreens. J Eur Acad Dermatol Venereol. 2019 Jul;33(7):1261-1267. 

Yarosh DB, Rosenthal A, Moy R. Six critical questions for DNA repair enzymes in skincare products: a review in dialog. Clin Cosmet Investig Dermatol. 2019;12:617-624.


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Spotlight on Skin was created by award-winning Melbourne-based dermatologist, Dr Julia Rhodes.

Julia knows first-hand how overwhelming the skincare world can be, and that’s with over 10 years of experience practicing dermatology. Given that even she gets overwhelmed, she appreciates how hard it can be for those of you without a scientific background to make sense of all the information available, and choose products that are right for your skin…